Ann Romney Center for Neurologic Diseases

Ann Romney Center for Neurologic Diseases

Ann Romney Center for Neurologic Diseases

ABOUT THE ANN ROMNEY CENTER FOR NEUROLOGIC DISEASES

The Ann Romney Center for Neurologic Diseases is transforming the future of medicine through novel forms of collaboration and patient-centered research. This collaboration—within and outside our walls—is accelerating the search for treatments, prevention, and cures for five of the world’s most complex neurologic diseases.

By combining Brigham and Women’s Hospital’s unique assets with the world’s most advanced resources and minds, the center is pursuing life-giving breakthroughs that are providing enduring hope and empowerment to individuals confronting these devastating neurologic diseases and changing outcomes for future generations.

The Ann Romney Center for Neurologic Diseases is a catalyst that fuels collaboration among the global medical and scientific communities in pursuit of treatments and cures for neurologic diseases.

 


LEADERSHIP

Howard L. Weiner, MD
Co-director, Ann Romney Center for Neurologic Diseases

 

Howard L. Weiner, MD Howard L. Weiner is the Robert L. Kroc Professor of Neurology at Harvard Medical School, director and founder of the Partners Multiple Sclerosis Center, and co-director of the Ann Romney Center for Neurologic Diseases at Brigham and Women’s Hospital. Dr. Weiner established the Partners Multiple Sclerosis Center at Brigham and Women’s Hospital in 2000, which combines clinical evaluation, MRI imaging, and immune monitoring, and is the first integrated MS center that brings these disciplines to the individual care of the MS patient. Dr. Weiner has pioneered the use of immunotherapy and the drug cyclophosphamide for the treatment of multiple sclerosis and has investigated immune abnormalities in the disease, including the role of the innate immune system and regulatory T cells. He has also pioneered the use of the mucosal immune system for the treatment of autoimmune and other diseases. Based on his work, vaccines are being tested in multiple sclerosis, diabetes, and most recently in Alzheimer’s disease. Dr. Weiner is the author of Curing MS: How Science is Solving the Mystery of Multiple Sclerosis, which chronicles the history of MS and his 30-plus years in the research and clinical treatment of MS, and details his “21 point hypothesis” on the etiology and treatment of multiple sclerosis.

 


Dennis J. Selkoe, MD
Co-director, Ann Romney Center for Neurologic Diseases

 

Dennis Selkoe, MD Dennis J. Selkoe is the Coates Professor of Neurology at Harvard Medical School and co-director of the Ann Romney Center for Neurologic Diseases at Brigham and Women’s Hospital. After graduating from Columbia University with a BA and the University of Virginia with an MD, he trained at the NIH, Harvard/Longwood Neurology, and the HMS Department of Neuroscience. Dr. Selkoe and his colleagues isolated the tangles of Alzheimer’s disease (AD) and co-discovered their antigenic relationship to tau. His research on amyloid ß-protein and APP led to the “amyloid hypothesis” of AD, which has helped provide the underpinning of numerous clinical trials, including the world’s first prevention trial in older individuals at risk for developing Alzheimer’s disease. His lab discovered that Aß is produced by cells throughout life, enabling the dynamic study of Aß generation and screens for inhibitors. They showed that APP and presenilin mutations cause AD by altering Aß production. With Michael Wolfe, PhD, Dr. Selkoe identified presenilin as the γ-secretase, the first intramembrane aspartyl protease in biology. Dr. Selkoe has received many honors for his work, including the Pioneer Award and Lifetime Achievement Award from the Alzheimer’s Association. He was the principal founding scientist of Athena Neurosciences, and is now a founding director of Prothena Biosciences.

 


ADVISORY BOARD

 

Ann Romney
Governor Mitt Romney
Katherine Kaneb Bellissimo
Neil Cavuto
Sandy Edgerley
DeLaine Emmert
John F. Fish
Mary Margaret Flatley Darling
Patricia Flatley
Philip Friedmann
Congressman Joseph Kennedy III
Carrie Marriott
Audrey McNiff
Marc Mezvinsky
Meredith Vieira (Honorary)
Montel Williams
Spencer Zwick

 


BRIGHAM AND WOMEN’S HOSPITAL LEADERSHIP

 

Elizabeth G. Nabel, MD
Howard L. Weiner, MD
Dennis J. Selkoe, MD

 


 

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