Ann Romney Center for Neurologic Diseases

Ann Romney Center for Neurologic Diseases

Ann Romney Center for Neurologic Diseases

HOW THE DISEASE AREAS INTERACT

 

The Ann Romney Center for Neurologic Diseases is founded on the belief that interdisciplinary collaboration, at Brigham and Women’s Hospital (BWH) and beyond, will accelerate global innovation and discovery in neurologic disease. Promising advances in neurologic diseases occur when research in one disease state is applied to other disease states, yielding breakthroughs that could not have occurred if the research remained in silos. For example:

 

    • By studying the role of the immune system in MS, Dr. Weiner’s lab created an antibody for regulating aspects of the immune system. When MS researchers shared this antibody information with researchers working on glioblastoma, one of the most deadly forms of brain tumors, it sparked the idea to test how the antibody would impact brain tumors. The researchers found the antibody worked successfully and could lead to potential new treatments for brain tumors—an exciting and unexpected discovery that would not have occurred without the cross-disease collaboration that the Ann Romney Center for Neurologic Diseases specializes in.
    • BWH’s successful research in Alzheimer’s is now fueling a potential breakthrough in Parkinson’s research. Drawing from Dr. Selkoe’s Alzheimer’s discovery about the role of amyloid protein, his team of Parkinson’s researchers has focused on a previously misunderstood protein called alpha-synuclein. They found a structural alteration of this protein in cells from patients with Parkinson’s. This important finding lays the groundwork for future research in the broader neurologic community and could lead the way to novel treatments of Parkinson’s disease.

 


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