The Stepping Strong Center for Trauma Innovation

The Stepping Strong Center for Trauma Innovation

Su-Ryon Shin, PhD, and Indranil Sinha, MD

2017 Winners: Su-Ryon Shin, PhD, and Indranil Sinha, MD

Su-Ryon Shin, PhD
Research Scientist, Department of Medicine, Brigham and Women’s Hospital
Instructor, Harvard-MIT Health Science & Technology

Indranil Sinha, MD
Associate Director, Brigham and Women’s Hospital Trauma and Burn Center
Assistant Professor of Plastic Surgery, Harvard Medical School

Restoring Skeletal Muscle Mass and Function Using 3D Bioprinting

In 2017, two previous Innovator Award winners, Su-Ryon Shin, PhD, and Indranil Sinha, MD, joined forces to explore skeletal muscle regeneration following volumetric muscle loss injuries, which affect approximately 500,000 trauma patients each year. Together, they have developed 3D-printed bio-scaffolds that have been successfully implanted in animal models with volumetric muscle loss injuries. With the additional Stepping Strong funding, the team will create a customized scaffold that mimics the properties of human muscle tissue, incorporates muscle growth factors, and delivers muscle stem cells to the injured area following volumetric muscle loss. The new project has the potential to revolutionize healing in patients with profound muscle injuries.

Su-Ryon Shin, PhD, received a doctoral degree from Hanyang University, South Korea. In 2010, she joined the staff at Brigham and Women’s Hospital (BWH) and Harvard Medical School (HMS), as a postdoctoral research fellow in the Division of Medicine. Shin was promoted to instructor at HMS in 2014 and is affiliated with the Wyss Institute for Biologically Inspired Engineering and the Harvard-MIT Division of Health Sciences and Technology. Shin’s interdisciplinary approach has earned her a growing international reputation for her work in nanomaterials science, regenerative medicine, and biomedical engineering. Her research focuses on developing micro- and nano-scale technologies to control and monitor cellular behavior, with particular emphasis on developing micro-scale biomaterials and engineering systems for biomedical applications. Her recent work focuses on multifunctional cardiac scaffolds and 3-D biohybrid actuators using biocompatible hydrogel for both therapeutic purposes and in vitro studies. Her team is currently developing a bioprinting technology to control cellular behavior and regulate cell alignment within engineered systems.

Indranil Sinha, MD, is a plastic surgeon at Brigham and Women’s Hospital (BWH). Sinha earned his undergraduate degree at the University of California, Berkeley, and then completed medical school training at the University of Michigan, where he was inducted into the Alpha Omega Alpha Honor Society. Sinha completed his internship at BWH and went on to train in plastic surgery in the Harvard plastic surgery training program in 2014. His research interests include skeletal muscle stem cells and their implications, particularly how the skeletal muscle regenerative potential decreases with aging and how muscle stem cells can be used to treat volumetric loss.  He is currently the lead investigator or co-investigator on three NIH-funded grants.