Stepping Strong Program: Bone Healing and Regeneration

Stepping Strong Program: Bone Healing and Regeneration

Collagen patches with nanoparticles promote bone growth and wound healing

Injuries from severe trauma accidents can cause large open bone fractures and bone defects that are prone to poor bone healing and high rates of infection following orthopaedic trauma surgery. To minimize the need for patients to have follow-up surgeries after trauma, and even to prevent amputations, 2015 Stepping Strong Innovator Award winner Omid Farokhzad, MD, MBA, in collaboration with Mitchel B. Harris, MD, and Morteza Mahmoudi, PhD, successfully developed collagen patches with nanoparticles—small, biodegradable robots—that can deliver antibiotics and other drugs to promote bone growth and wound healing in trauma patients in a safer, controlled, and more efficient way than current approaches.

With the additional Stepping Strong funding, Farokzhad and his team plan to enhance their product, apply the patches in animal models, and then facilitate the clinical translation of the product, with commercialization anticipated in two to three years.